Emma S. Guns, Ph.D.
Research Scientist, The Prostate Centre at
Vancouver General Hospital
Assistant Professor of Surgery, Faculty of Medicine, University
of British Columbia
Jack Bell Research Centre
2660 Oak St.
Canada V6H 3Z6
Office: 604 875-4111 ext. 63430
Fax: 604 875-5654
of natural health products for prostate cancer. Emma Guns, BSc.
PhD, is a Research Scientist at The Prostate Centre at Vancouver
General Hospital and a faculty member of the Department of Surgery
(Assistant Professor) and Pharmaceutical Sciences (Associate
Member) at The University of British Columbia. Dr. Guns coordinates
the complementary/alternative therapy research program at The
Prostate Centre and is a pharmacologist with a specialised interest
and experience in drug metabolism, drug transport, pharmacokinetics,
multi-drug resistance to chemotherapy and tumor models in vivo.
Her research group comprises of postdoctoral fellows: Sherwin
Xie and Simon Cowell, graduate student: Andy Eberding and research
technicians: Candice Madera and Catherine Wood whose work focuses
upon the use of naturopathic treatments and dietary supplements
with advocated therapeutic efficacy for prostate cancer. Current
compounds/therapies of study include High pH therapy, ESSIAC,
ginsenosides and PC-SPES and these alternative treatments are
currently being tested in prostate tumor models to investigate
pharmacokinetics, toxicity, metabolism and if relevant, molecular
mechanism of the action. Dr. Guns research group is also investigating
the combination of natural products with conventional chemotherapy
to determine the incidence of potential interactions posing
as hazard or benefit to therapeutic efficacy.
Dr. Guns has been recently involved in the analysis of conventional
therapeutics in clinical trials for the treatment of prostate
cancer. Her research lab has validated HPLC analytical methods
for the purpose of quantifying paclitaxel as well as antisense
oligonucleotides derived from human sera for trial sample analysis
on a collaborative basis.
Eng, J, Ramsum, D, Verhoef M, Guns, E., Davison B.J. and Gallagher R. A population based survey of complementary and alternative medicine use in men recently diagnosed with prostate cancer. Integrative Cancer Therapies 2 (3) : 212 - 216. 2003
Guns ES, Denyssevych T, Dixon R, Bally MB, Mayer L. Drug interaction studies between paclitaxel (Taxol) and OC144-093--a new modulator of MDR in cancer chemotherapy. Eur J Drug Metab Pharmacokinet 27 (2) : 119 - 126. 2002